JUVGEN: Can it improve skin firmness and under-eye dark circles? Research on carbon dioxide and hyaluronic acid

Research examining JUVGEN itself was not found within the scope of this investigation. The component materials—carbon dioxide injection and hyaluronic acid injection—each have reports demonstrating effects on skin firmness and under-eye dark circles[1][2]. However, large comparative trials are still lacking, and the combined effect of the two has not been confirmed[2].

What does JUVGEN inject?

JUVGEN is a treatment that alternately injects medical-grade carbon dioxide and hyaluronic acid into shallow layers of the skin. The method of injecting carbon dioxide into the skin is called 'carboxytherapy'[1].

When carbon dioxide enters, oxygen more readily diffuses from the blood to surrounding tissues, and blood flow is thought to increase[3][4]. Reports also indicate that it promotes collagen remodeling within the skin[4].

How does the skin change with carbon dioxide injection?

Carbon dioxide injection has been used for skin aging and under-eye dark circles[1]. A research summary indicates that topical carbon dioxide formulations can also be expected to improve under-eye dark circles[3]. When injected subcutaneously, reports show that skin thickness increases and capillary flow improves[4].

On the other hand, drawbacks have been noted: effects may be less than expected, unintended fat loss, and air remaining beneath the skin for prolonged periods[5]. Most research uses varying methods, making simple result comparison difficult[3].

Does hyaluronic acid injection change skin firmness?

Research consistently shows that injecting hyaluronic acid into the skin improves skin quality. A summary of 13 studies found improvements in hydration, firmness, elasticity, brightness, and texture, with high satisfaction reported[2].

However, large randomized controlled trials (studies comparing treatments by randomization) are still noted as insufficient[2]. It has also been reported that hyaluronic acid alone showed clearer effects compared to formulations mixed with other ingredients[2].

What precautions should be taken when using it under the eyes?

Under-eye skin is thin, and injected material can easily surface. Cross-linked hyaluronic acid placed under the eyes is more likely to cause nodules, irregularities, and a bluish, translucent appearance (Tyndall effect)[6].

Hyaluronic acid injection in general carries reports of skin necrosis and blindness when material enters blood vessels[7]. Serious eye-related complications are rare, but early detection and prompt management are critical[8]. If you notice vision changes, severe pain, or skin color changes after injection, contact your clinic immediately.

What about pain and downtime?

Carbon dioxide injection can be quite painful for some people[9]. Since the procedure uses a needle, infection risk is not zero[9].

Research on how long swelling or bruising lasts with JUVGEN was not found. When timing matters for your schedule, it is reassuring to ask your doctor for an estimate during consultation.

What should I confirm before treatment?

During counseling, ask about the following points:

Concerns: whether fine lines, lack of firmness, or under-eye dark circles are the primary issue[1][2]

Under-eye area: how to manage if nodules or bluish appearance develop[6]

Pain: what measures are available to reduce discomfort, such as anesthesia or cooling[9]

Other treatments: how hyaluronic acid injection alone or other procedures compare[2]

Whether JUVGEN suits your specific skin concerns cannot be determined from an article alone. During consultation, have your doctor examine the skin thickness in the area of concern and the cause of your dark circles, then confirm the differences from other options and estimate the number of sessions needed.