JUVGEN, where should I get it? Distinguishing clinics by their preparedness for hyaluronic acid vascular complications

Since JUVGEN is a procedure that injects carbon dioxide gas and hyaluronic acid into the skin, the basic rule is to choose a clinic that is prepared to handle situations where hyaluronic acid enters blood vessels[1][2]. Hyaluronic acid injection has rarely been associated with serious complications such as skin necrosis and blindness[1]. Research on the JUVGEN combination itself is not yet available, so effects should be considered as appearing gradually.

Can hyaluronic acid vascular complications be treated right away?

First, you should look at preparedness for vascular complications. When hyaluronic acid blocks a blood vessel, it can lead to serious complications such as skin necrosis, blindness, and cerebral infarction[2]. The Japanese Society of Aesthetic Surgeons' guidelines also recognize hyaluronic acid injection for facial wrinkles as effective, but note that care is needed to avoid accidental intravascular injection[1].

Hyaluronic acid-dissolving medication (hyaluronidase) is very effective as a treatment for when blood flow is blocked[2]. Check whether the clinic has a system to use this medication immediately and whether there is a contact point available even on the evening of the procedure.

People with allergies to bee stings or allergies to bovine collagen may have a reaction to this medication[3]. Please disclose your allergy history at the start.

Are side effects of carbon dioxide gas injection explained?

The most common side effect of carbon dioxide gas injection is small bruising at the injection site. Most bruises fade within a few days and leave no scarring, according to reports[4].

On the other hand, gas remaining under the skin for extended periods (subcutaneous emphysema), unintended fat reduction, and failure to achieve expected results are also listed as drawbacks[5]. It is reassuring to also ask where to consult if swelling at the injection site does not subside.

How many sessions? When should I evaluate the results?

JUVGEN is not a procedure that produces dramatic changes in a single session. Carbon dioxide gas injection is said to improve blood circulation and help rejuvenate the skin by reorganizing collagen within the skin[6].

In research on depressed acne scars, 32 people received 6 sessions of carbon dioxide gas injection on one side of the face, and all types of acne scars became less noticeable[4]. However, it has been pointed out that the amount and method of carbon dioxide gas therapy are not yet fully established[7]. Deciding in advance at what session to reassess results will help you avoid uncertainty.

For depressed acne scars, do they compare it with other treatments?

For deep acne scars, whether the clinic compares it with other treatments is also an important consideration. The Japanese Dermatological Association's guidelines do not recommend hyaluronic acid and other injectable treatments for depressed acne scars (recommendation grade C2)[8].

Acne scar treatment has multiple options including carbon dioxide gas injection, microneedling therapy, and lasers[4]. Choose a clinic that explains multiple options without recommending just one procedure.

Where should I get it? A guide when you are unsure

During consultation, ask the following points:

Vascular complications: Can the clinic use hyaluronic acid-dissolving medication immediately?[1][2]

Allergies: Does the clinic ask about your history of bee sting or collagen allergies?[3]

Side effects: Does the clinic mention that bruising, subcutaneous emphysema, and failure to achieve results can occur?[5][4]

Other treatments: For acne scars, does the clinic explain comparison with lasers and other options?[4][8]

Whether JUVGEN suits your wrinkles or acne scars and how many sessions you need cannot be decided by this article alone. During consultation, have the doctor examine the depth of depressions and presence of sagging, and discuss with the physician while comparing other treatments.