PRP (injection using your own blood): Where to get it? Choose based on explanation of how it's made and realistic expectations

PRP (treatment that collects platelets from your own blood and injects them) is best received at a clinic that specifically explains how it is made and what results can realistically be expected[1]. This is because PRP production methods and volumes are not standardized, and even products labeled the same 'PRP' can differ in composition[1]. PRP with added growth factors is not routinely recommended due to higher rates of complications such as nodules[2].

What can be expected from PRP, and where are the limitations?

PRP is expected to improve fine lines, skin texture, and acne scars[1]. A report summarizing 36 studies and 3,172 patients on facial rejuvenation showed that in 36 studies, all but 7 (19.44%) reported clear improvement[1].

However, most studies had small sample sizes, with a median of 27.5 participants per study[1]There has long been caution noted against PRP being advertised as though it works for everything.[3].

In domestic research, PRP was injected into one half of the face and saline into the other half for comparison.[4]In the results from 9 subjects, skin luster increased 16.3% more on the PRP side after one month.[4]Since this is a report of interim results with a small number of subjects, treat it as a reference point.

Can you explain how it's made (centrifugation and concentration)?

When choosing PRP, make sure the provider explains how it's prepared. The number and speed of centrifugation cycles (the process of spinning blood to separate its components) and whether white blood cells are included affect the platelet concentration and the quantity of growth factors.[5].

In a summary of hair loss research, the preparation method using two centrifugation cycles was reported to be more effective than the single-cycle method.[6]Asking about the preparation method, number of sessions, and intervals between treatments will make it easier to compare with other clinics.

If PRP is used for hair loss, will they start by testing for the underlying cause?

When PRP is used for hair loss, it is important that the clinic first confirms the cause. In research, blood tests for anemia, thyroid function, hormones, and other conditions were used to rule out hair loss from other diseases[7]Screening for infection is also considered essential before PRP treatment[7].

PRP for hair loss is thought to be more effective in the early stages before significant progression, and less effective in advanced cases[5]See whether they honestly discuss how much improvement can be expected at your current stage.

What do you think about PRP with added growth factors?

PRP with added growth factors (bFGF) is a treatment that warrants careful consideration. According to guidelines from the Japanese Society of Aesthetic Surgeons, complications such as nodules (hardening) and swelling are common, and it is not recommended without careful deliberation[2].

Even when using PRP alone, care must be taken to avoid accidental injection into blood vessels[2]Side effects are rare, with the main ones being bruising and swelling from the injection[8]Choose a clinic that clearly answers what is or is not mixed into the PRP.

Where should you receive treatment? Guidelines when you are unsure

At your consultation, ask about the following points.

Expectations: Can they discuss what improvements are possible and to what extent, including limitations?[1][3]

Preparation method: Can they explain the centrifugation technique, number of sessions, and intervals between treatments?[5][6]

Additives: Can they answer whether growth factors or other substances will be added?[2]

Testing: For hair loss, will they perform blood tests to investigate the underlying cause?[7]

Whether PRP is right for your skin or hair cannot be decided from an article alone. At your consultation, share your primary concern and your treatment history, and discuss the preparation method, number of sessions, and how this treatment differs from other options with your doctor.