If you choose Volbella XC, look for a provider who injects gradually while accounting for blood vessel location in the lips and under-eye area, and who explains how to manage swelling and nodules. Although the filler is soft and easy to shape, the under-eye area has thin skin where even minor irregularities are conspicuous.[1]Results depend more on injection technique than on the filler itself.
What concerns is Volbella XC suited for?
Volbella XC is a soft hyaluronic acid used for hollows in the lips, mouth area, and under-eye region[1]It contains 15 mg of hyaluronic acid per 1 mL, with 0.3% lidocaine, a numbing anesthetic[1].
Because it spreads and reshapes easily, it is well-suited for fine adjustments in small areas[1]Conversely, for areas like the cheeks where you want significant volume added, a different filler is often considered.
How long does it last? What about the second treatment?
Lip fullness gradually diminishes over time. In a study of 124 people, lip fullness improvement was observed in 86.2% at 1 month, 80.3% at 3 months, and 61.8% at 1 year[2].
When a second injection was given at 1 year, improvement was seen in 94.3% of people at 1 month[2]The amount used was also reduced to 1.5 mL compared to 2.6 mL at the first treatment[2]Whether to continue is best decided by assessing the condition around the 1-year mark.
Is swelling or nodules common with lip and under-eye injections?
Lips and mouth area are places where swelling, nodules, and firmness commonly develop. Research summarizing hyaluronic acid trials found these effects more frequently in lips and mouth than in nasolabial folds[3].
Delayed inflammation is also a concern. One paper reported that in a review of 400 people who received Volbella in the lips and under-eye area, 4.25% experienced prolonged or recurrent inflammation[4]Ask in advance whether the clinic can manage you if swelling persists.
Where do results differ?
Results differ based on knowledge of blood vessel location and injection depth. For lip injection, anatomical knowledge of blood vessel location is essential, and injection depth is considered especially important[5]The amount should be kept to the minimum needed to achieve the desired shape[5].
Guidelines also warn that inadvertent injection into blood vessels can cause skin necrosis or blindness[6]Since hyaluronic acid can be dissolved with hyaluronidase, verify that the clinic can use this medication immediately[7].
Where should I go? Checklist if you're unsure
During consultation, ask about these points:
Site assessment: Where in the lips, mouth area, or under-eye region, and how much filler?[1]
Injection technique: Do they explain blood vessel location and injection depth?[5]
Emergency readiness: Can they immediately use hyaluronidase if needed?[6][7]
Follow-up: Can you be seen if swelling or nodules persist?[3][4]
Whether Volbella XC is right for your lips and under-eye area cannot be decided from an article alone. At your consultation, tell your doctor which areas concern you and what shape you want, then discuss the amount, injection method, and timing of a second treatment.
- 1Fabi S, Zoumalan C, Fagien S, Downie J, Yoelin S, Sartor M, Chawla S. Effectiveness of Volbella (VYC-15L) for Infraorbital Hollowing: Patient-Reported Outcomes From a Prospective, Multicenter, Single-Blind, Randomized, Controlled Study. Aesthetic Surgery Journal. 2023. doi:10.1093/asj/sjad100
- 2Rivkin AZ, Weinkle S, Hardas B, Weiss R, Glaser D, Biesman B, et al. Safety and Effectiveness of Repeat Treatment With VYC-15L for Lip and Perioral Enhancement: Results From a Prospective Multicenter Study. Aesthetic Surgery Journal. 2018. doi:10.1093/asjour/sjy019
- 3Colon J, Mirkin S, Hardigan PC, Elias MJ, Jacobs RJ. Adverse Events Reported From Hyaluronic Acid Dermal Filler Injections to the Facial Region: A Systematic Review and Meta-Analysis. Cureus. 2023. doi:10.7759/cureus.38286
- 4Li Q, Cui H, Tseng FW, Liu Q, Xue Z, van Loghem J, et al. The Assessment, Strategy, and Treatment Protocol: Nasolabial Fold Assessment, Strategy, and Treatment With Hyaluronic Acid Fillers in Chinese Patients. Plastic and Reconstructive Surgery Global Open. 2025. doi:10.1097/GOX.0000000000006792
- 5Menezes MVA, Dezanetti CBG, Penna FWP, Cury RSL, de Aquino SBG. Aesthetic Treatment of the Lips With Hyaluronic Acid Filler: The Multi Vector Lip Technique. Journal of Cosmetic Dermatology. 2025. doi:10.1111/jocd.70445
- 6Japanese Society of Aesthetic Surgeons, Aesthetic Medical Care Clinical Practice Guideline, CQ2-2-1 (Hyaluronic acid formulation injection is effective for facial wrinkle treatment, but caution is warranted because of reports of serious complications such as skin necrosis and loss of vision due to intravascular injection. Recommendation level 2, weakly recommended.)
- 7Cummings Otolaryngology: Head and Neck Surgery, 7th ed. Chapter 17: Atrophic and Depressed Scar Management (Hyaluronic acid filler can be reversed with hyaluronidase, and effects typically last 3–12 months.)