Nodules from fat grafting breast augmentation are primarily caused by fat necrosis and oil cysts (accumulation of oil), and it is thought that they can be reduced to some extent depending on the fat processing method[1]However, comparisons that clearly conclude the superiority or inferiority of different processing methods remain limited[2]We will organize what is known and what to look for when making a choice.
What is the basic flow of fat grafting breast augmentation?
The harvested fat is processed and transferred in small amounts across multiple layers of the breast[3]The glandular tissue is avoided as much as possible, and the fat is dispersed into the subcutaneous layer and areas beneath the muscles.[3]This "processing" and "how the fat is distributed and transferred" are related to how readily nodules form and how well the graft takes.
Why do nodules form?
Most nodules are fat necrosis, where fat that did not take hold hardens, or oil cysts formed by the accumulation of oil[4][1]It has been pointed out that oil mixed from fat that broke during harvesting is one factor in the formation of oil cysts.[1]A systematic review of processing methods also repeatedly reports fat necrosis and nodules as major complications[4].
Can processing methods reduce lumps?
The main strategy for reducing oil cysts is processing in the direction of "removing oil and concentrating,"[1]. However, there is wide variation in reports regarding which method—centrifugation, washing, or filtration—is most effective, and no definitive conclusion has been reached.[2]Processing method is an important factor, but the result is not determined by it alone.
What about calcification and impact on breast cancer screening?
After fat injection, changes such as calcification and fat necrosis may appear on mammography and ultrasound.[5]. Most follow benign patterns, but since differentiation may be needed during breast cancer screening, it is important to inform the screening facility that fat was injected.[6]. Whether it is easy to continue regular screening may also be a perspective to consider when choosing.
What to confirm in consultation
What you should confirm is which processing method will be used to reduce lumps, the approach to the amount injected at one time and the number of sessions, and preparations for calcification and screening impacts.[2][1][6]. There are individual differences in engraftment and complications. Ask your physician about the reasons for choosing the processing method and the long-term approach assuming continued screening, and use this as a basis for your decision.
- 1Ma N, Li S, Liu C, et al. Oil Cysts after Fat Grafting Breast Augmentation May Be Avoided. Plastic & Reconstructive Surgery. 2026. doi:10.1097/prs.0000000000012446
- 2Condé-Green A, Wu IW, Graham IA, et al. Comparison of 3 Techniques of Fat Grafting and Cell-Supplemented Lipotransfer in Athymic Rats. Aesthetic Surgery Journal. 2013. doi:10.1177/1090820X13487371
- 3Neligan PC, et al (eds). Plastic Surgery, 5th ed. Section on Breast Augmentation by Autologous Fat Transfer (Harvesting, Processing, and Multi-layer Injection).
- 4Seth I, Bulloch G, Gibson D, et al. Autologous Fat Grafting in Breast Augmentation: A Systematic Review Highlighting the Need for Clinical Caution. Plastic & Reconstructive Surgery. 2024. doi:10.1097/PRS.0000000000010614
- 5Veber M, Tourasse C, Toussoun G, et al. Radiographic Findings after Breast Augmentation by Autologous Fat Transfer. Plastic and Reconstructive Surgery. 2011. doi:10.1097/prs.0b013e318205f38f
- 6Veber M, Tourasse C, Toussoun G, et al. Radiographic Findings after Breast Augmentation by Autologous Fat Transfer. Plastic and Reconstructive Surgery. 2011. doi:10.1097/prs.0b013e318205f38f
- 7Japan Association of Plastic Surgeons (eds). Plastic Surgery Clinical Practice Guidelines 1 (2021 Edition). Section on Breast Reconstruction CQ28 Autologous Fat Injection Method.