PluRial
A skin-conditioning agent that strengthens the skin itself by supplementing the skin's intrinsic self-repair capacity
Recommended for
- I want to improve dry skin
- I want to improve facial redness and uneven skin tone
- Deep wrinkles and fine lines on the face concern me
- I want to reduce wrinkles on the neck
- I want firmer, more elastic skin
- I have concerns about allergies
Stronger and more beautiful skin from deep within
"PluRial Densify" is an innovative biostimulator (bioactive stimulus) preparation focused on skin regeneration, developed by MD Skin Solutions in Luxembourg and holds "CE marking" certification, with a track record of use in over 20 countries. It is a filler that primarily approaches the skin's unique self-repair capacity as a new injectable.
?
【Products handled at our clinic】
● PluRial Densify
● PluRial BioSculpture
● SkinPlus
Features
"Biostimulator preparations" gaining attention in recent years
■ Bio (biological) + Stimulation (stimulus) ■ Targets declining skin function and cells themselves ■ Main ingredient uses polynucleotides (PN) with established safety for the human body Most previous injectable products aimed to supplement depleted skin moisture and collagen, but this series uses polynucleotides (PN) derived from salmon as its main ingredient and employs biostimulation (bioactive stimulus) that activates fibroblasts to promote skin repair and regeneration. In this process, it addresses wrinkles and sagging (skin laxity) while delivering beautiful skin effects, and simultaneously improves dermatitis and wounds, creating stronger skin.
Main ingredient "Polynucleotide (PN)"
■ Component extracted from salmon or trout DNA ■ High compatibility with skin ■ Promotes tissue repair, anti-inflammatory action, antioxidant action, angiogenesis ■ Reduces inflammatory cytokines that trigger aging symptoms ■ Increases various growth factors ■ Comprehensive beautiful skin effects including wrinkles and wound healing When polynucleotides (PN) are injected into the body, cells misinterpret the damage, activating tissue regeneration and skin repair. Anti-inflammatory action is exhibited and cytokines are released. Simultaneously, collagen production is promoted, leading to beautiful skin.
High-safety preparation
"PluRial Densify" complies with EU regulations and has obtained "CE marking" certification guaranteeing safety in Europe. By increasing polynucleotide purity and completely removing proteins, allergen risk is greatly reduced, achieving a high-safety preparation design. What is CE? CE refers to the institution equivalent to Japan's Ministry of Health, Labour and Welfare. By meeting safety performance standards set by EU law, the CE mark can be displayed on the product.
DENSIFY Densify
■ Uniquely formulated with PN, non-crosslinked hyaluronic acid, and mannitol ■ Increased PN purity and complete protein removal reduce allergen risk ■ Enables full-face skin quality improvement ■ Effective for improving firmness and radiance A new preparation uniquely formulated with non-crosslinked hyaluronic acid and mannitol added to polynucleotides (PN). Through the synergistic effect of three beauty ingredients, the stimulating action on cells and tissues is higher than performing treatment with each component individually. Even a single injection efficiently approaches the skin and the effects last longer. It is suitable for injection into the entire face, neck, and décolletage, leading to refined skin by addressing dryness and sebum-related skin troubles, and insufficient firmness or volume.
BIOSCULPTURE BioSculpture
■ Three types of hyaluronic acid formulated using special technology ■ Achieves lasting effects + skin regeneration ■ Addresses deeper wrinkles and sagging (skin laxity) ■ Less likely to trigger allergic reactions and safe ■ Because crosslinkers are minimal, dispersion in the body is easier and nodule formation is unlikely Composed of three types of hyaluronic acid: crosslinked hyaluronic acid (high and medium molecular weight) and non-crosslinked hyaluronic acid (low molecular weight), by formulating different types of hyaluronic acid in a unique ratio, both lasting effects and skin regeneration have been achieved. Specialized for those wishing to refine contours, restore facial volume lost with age, and skin quality improvement.
What is SkinPlus
A skin-building injection that supplements skin-supporting components such as human-derived collagen. It addresses the foundation of the skin, improving firmness, elasticity, and texture to achieve smooth, radiant skin. ■Notice regarding unapproved pharmaceuticals and medical devices ・SkinPlus (CellREDM™, manufactured by HansBioMed, South Korea) used in this treatment has not been approved under the Pharmaceutical Affairs Law in Japan. ・It is obtained through personal importation under the judgment of our clinic physician. ・There are no domestic-approved pharmaceuticals or medical devices with identical composition or performance. ・The possibility remains that serious risks or side effects have not been identified. ・If severe adverse effects occur, coverage under Japan's Pharmaceutical Damage Relief System does not apply. ・Because it contains human-derived components, blood donation may be restricted. Please inform the blood donation center that you have undergone this treatment.
Treatment details
- Treatment time
- 10–20 minutes (plus 30 minutes for topical anesthesia if needed)
- Interval between sessions
- Densify: Every 2–4 weeks for 3 sessions (recommended) BioSculpture: Every 1–2 months for 1–3 sessions (recommended)
- Pain during treatment
- Injection pain present (combination of topical anesthesia, block anesthesia, or nitrous oxide anesthesia recommended)
- Risks
- Bruising, redness, swelling, edema, etc.
- Shower and bathing
- Shower: Possible from the same day (water rinsing of the treated area possible 6 hours later) Bathing: Possible 24 hours later
- Makeup and skincare
- Makeup: Possible 24 hours later Cleansing foam and makeup remover: Possible 24 hours later (water rinsing of the treated area possible 6 hours later) Toner and lotion: Possible 6 hours later Makeup and sunscreen: Possible 24 hours later
Pricing
■ PluRial Densify
| Treatment | Unit | Price (incl. tax) |
|---|---|---|
| Partial injection (2cc) | 1 session 3 sessions |
|
| Full-face injection (4cc) | 1 session 3 sessions |
|
■ PluRial BioSculpture
| Treatment | Price (incl. tax) |
|---|---|
| 1 vial (1.1ml) |
|
■ SkinPlus
| Treatment | Price (incl. tax) |
|---|---|
| SkinPlus |
|
| SkinPlus + Densify 2cc |
|
| SkinPlus + Densify 4cc |
|
※ All prices include tax.
FAQ
How long do the effects of PluReal last?
While results vary by individual, the improvement in skin firmness and moisture from a single treatment typically persists for approximately 3–6 months. By continuing regular maintenance (every 3–4 months), biostimulator effects accumulate and longer-term skin quality improvement can be expected. Because the polynucleotide (PN) component activates fibroblasts within the dermis, collagen production is promoted, and with repeated treatments the skin's intrinsic strength itself improves.
Ask ZetithAI about this →How much downtime is there after treatment?
Mild redness, swelling, and bruising from injection may occur but typically resolve within 2–3 days. In most cases makeup is possible immediately after treatment; however, intense exercise, alcohol, and sauna should be avoided on the day of treatment. Strong stimulation to the injection site should also be avoided for several days. Because visible downtime is minimal, it is an accessible treatment even for busy individuals.
Ask ZetithAI about this →What is the difference between this and hyaluronic acid injection (filler)?
PluReal is a biostimulator formulation intended for skin building and differs fundamentally from hyaluronic acid filler. Filler works by injection to immediately provide physical volume supplementation, but PluReal's main component, polynucleotide (PN), stimulates fibroblasts at the cellular level and promotes the skin's own collagen and elastin production. Rather than immediate volume enhancement, it is an approach closer to "skin regenerative medicine" that elevates skin quality and skin strength themselves.
Ask ZetithAI about this →Who is this treatment suitable for? Are there any people who cannot receive it?
It is particularly suited for those concerned with dryness, dullness, fine lines, or lack of skin firmness, those worried about allergies and uncertain about hyaluronic acid products, and those wishing to improve wrinkles on the neck and décolletage. On the other hand, it may not be possible for those who are pregnant or breastfeeding, those with infection or inflammation at the injection site, and those currently using immunosuppressants. Please feel free to contact us via LINE or phone for booking and consultation. We will explain in detail during your consultation.
Ask ZetithAI about this →Consultations about this treatment are free.
Book / free consult via LINE
Search this ID in WeChat to add us
zetith0123 ZetithBeauty_Ginza