Hydrating injections are best chosen from clinics that can explain the name and source of the injected medication, confirm your medical history, and perform the procedure under sterile protocols[1]. Because no standardized procedure was established before widespread use, complications such as nodules and infections have been reported[2]. This is a treatment to improve skin hydration and texture; it is not designed to fill deep wrinkles or alter facial contours[3].
Will the provider explain what is being injected?
First, look for whether the provider explains the name of the injected medication and the reason for choosing it. International consensus guidelines require that products be selected based on evidence of efficacy and biocompatibility, with clear explanation and informed consent before use[1].
There are reports of patients having hyaluronic acid obtained independently injected by hand, resulting in nodules appearing across the face[2]. In this case, it was also impossible to verify what the substance actually was[2]It is pointed out that injecting drugs not approved for injection into skin is dangerous.[4].
In China, as procedures to inject hyaluronic acid into skin with fine needles have become widespread, many side effects have been reported.[5].
Before injection, do they ask about pre-existing conditions and medications?
Checking pre-existing conditions and medications you are taking is also an important point of comparison. People taking blood-thinning medications are more prone to bleeding and bruising from needle punctures.[1].
Additionally, caution is necessary if you have an autoimmune disease, a keloid-prone constitution (where scars become raised), or active herpes.[1]People who already have undissolved fillers in the injection area or who have allergies are also advised to confirm this beforehand.[1].
Are clean procedures followed to prevent infection?
Whether clean procedures are being followed is a very important point. If cleanliness is insufficient, infection by nontuberculous mycobacteria can occur several months after injection.[6].
Infection by this bacterium is most commonly reported in aqua facial (water-light) injection infections.[4]This bacterium is resistant to antibiotics and treatment can take a long time.[4].
The informed consent document requires strictly adhering to clean procedures.[1]It is also recommended to change gloves after marking the injection sites on the face.[7].
If swelling or nodules appear, will the doctor examine me?
After injection, mild reactions such as redness, bruising, and swelling may occur.[6]Normally, there is minimal downtime (the period until swelling and bruising subside) with this treatment.[6].
Rarely, granulomas (nodule-like inflammatory masses) can form, and cases with difficult healing have been reported.[4][2]Additionally, with hyaluronic acid injection, if the substance enters blood vessels, serious complications such as skin necrosis or blindness can occur, so caution is necessary.[8]If nodules or redness persist for a long time, check whether the doctor will examine you promptly.
How many sessions? Guide to expected results
Water-light injection is a treatment that gradually refines the skin through multiple sessions rather than making drastic changes in one session.[3]For skin boosters, it is generally recommended to receive about 3 sessions at monthly intervals.[6].
The goal is to improve hydration, firmness, and skin texture—it is not a treatment for creating contours or filling deep wrinkles.[3]If deep wrinkles or sagging are your main concerns, a different treatment may be more suitable.
Where should I go? Guidelines when in doubt
During consultation, ask about the following points:
Medication: Can the doctor explain the name and source of the product, and the reason for choosing it?[1][2]
Medical history: Does the doctor ask in advance about blood-thinning medications or any physical conditions?[1]
Cleanliness: Does the clinic follow infection-prevention procedures and change gloves properly?[1][7]
Complications: If nodules or persistent redness occurs, will the doctor examine you?[4]
Which medication is right for your skin and how many sessions you need cannot be determined from an article alone. At your consultation, tell the doctor about your skin concerns, medical history, and current medications, and discuss the type of medication and number of sessions with them.
- 1Mammucari M, Russo D, Maggiori E, Rossi M, Lugli M, Marzo RD, et al. International Consensus Guidelines on the Safe and Evidence-Based Practice of Mesotherapy: A Multidisciplinary Statement. Journal of Clinical Medicine. 2025. doi:10.3390/jcm14134689
- 2Wang L, Chen SS, Xu MY, Liu YQ, Tang JT. Successful Treatment of Mesotherapy Induced Granuloma Annulare With Baricitinib. Journal of Cosmetic Dermatology. 2025. doi:10.1111/jocd.70162
- 3Pino A, Torrecilla J, Alonso JM, Tovito L, Pérez R. Clinical and Biometric Assessment of a Hyaluronic Acid-Based Skin Booster for Face, Neck and Décolleté Rejuvenation: A Prospective Study. Journal of Cosmetic Dermatology. 2025. doi:10.1111/jocd.70547
- 4Zhang Q, Yang L, Yang F, Liu L, Jiang X. Mesotherapy-Induced Cutaneous Foreign Body-Type Granulomatous Reaction in the Face Treated with Minocycline: Case Report and Literature Review. Clinical, Cosmetic and Investigational Dermatology. 2023. doi:10.2147/CCID.S403601
- 5Zhan N, Guo Q, Zou Y, Zeng Z. Consideration of Supervision of Mesotherapy Needles for Cosmetic Injection (in Chinese). Chinese Journal of Medical Instrumentation. 2023. doi:10.3969/j.issn.1671-7104.2023.02.016
- 6El Hawa M, Shahla WA, Fares C, Saade D. Non-Facial Skin Rejuvenation of the Neck, Chest, and Hands. Part One: Using Injections. Journal of Cosmetic Dermatology. 2025. doi:10.1111/jocd.16624
- 7Goodman GJ, Liew S, Callan P, Hart S. Facial aesthetic injections in clinical practice: Pretreatment and posttreatment consensus recommendations to minimise adverse outcomes. Australasian Journal of Dermatology. 2020. doi:10.1111/ajd.13273
- 8Bulletin of the Japanese Society of Cosmetic Surgeons, Special Issue (Vol. 44 Supplement). CQ2-2-1 Hyaluronic acid preparation injection for facial wrinkle treatment (recommendation level 2, weak recommendation).